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Ronald Klatz produced a good book on the subject called

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Lash et al., 2014)

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In osteoarthritis (OA), SHMT2 expression is elevated in chondrocytes, and miR-370 affects the pathological process of osteoarthritis by altering 1C metabolism and DNA methylation through negative regulation of SHMT2 expression [150]

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Second, since the majority of research on the pathophysiological role of UA in CVD was obtained from experimental studies, which were extrapolated to humans, more human studies should be performed to delineate the underlying mechanisms of the UA involvement in the pathophysiology of CVD

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Governed by specific writers, erasers and readers, these regulatory nodes are fundamental for understanding the lactylation landscape

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