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It is a designation used primarily by the FDA (Food and Drug Administration) for products, often in vitro diagnostic (IVD) components like reagents or instruments, that are in the laboratory research phase of development and are not intended for clinical diagnostic use

doi: 10.3390/ph16070977

All enrolled participants were weight stable, free from acute or chronic diseases, and did not eat a diet or take medications that might interfere with outcome markers including antioxidant supplements, high intake of dietary polyphenols including coffee, or anti-inflammatory medications

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Figure 1 2.2.1 Early exploration and basic protection (1990s) In the 1990s, nutraceutical scientists first explored nanocarriers largely inspired by pharmaceutical advances