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Research work has found a significant association between childhood maltreatment and lower resting state functional connectivity (rs-FC) between the hippocampus and amygdala with subgenual cingulate, with negative implications regarding internalizing symptomatology ( e.g ., anxiety/ depression, withdrawal, and loneliness) [19, 37]

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78 Importantly, our evidence indicated the safety of selenium supplementation at doses ranging from 80 to 400 g per day for up to 12 months by showing comparable adverse events between the selenium-treated and control groups, filling a notable gap where such safety analyses were lacking

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