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Further confirmation of fumarate as an oncometabolite was verified by experimental data showing that tumor cells lost their ability to invade and migrate when the function of fumarate hydratase was restored by an external expression vector 131

[DOI] [PubMed] Qian H, Chao X, Williams J, Fulte S, Li T, Yang L, et al

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Together, serine and glycine are the primary sources of one-carbon units used in the synthesis of nucleic acids, lipids, proteins, and cofactors (89)

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