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This motif recruits IRF3, which is then phosphorylated by TBK1, inducing its dimerization

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The potential metabolism-immune-neuro interaction framework of PEM is based on multi-level molecular crosstalk: mitochondrial dysfunction generates DAMPs that activate innate immune pathways (NLRP3, NF-B) to induce peripheral inflammation

doi: 10.1016/j.jpba.2015.12.020 91 YeHMLiZYZhangPKangZZhouDS