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Many phytochemicals are characterized by their ability to cross the blood-brain barrier and enter brain tissues with relative ease due to their chemical properties, such as being naturally lipophilic [186]

Psychoneuroendocrinology 134:105360

Acknowledgements We thank Simon Gilroy (Department of Botany, University of Wisconsin) for providing us with the GCaMP3 seeds

TABLE 4 Tools used for the assessment and diagnosis of pediatric CIPN

Results Our literature search yielded 14 human subject trials of either L-arginine alone or L-arginine in combination with other molecules for the treatment of EDs