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doi: 10.1164/rccm.200206-626OC 127 KilinGSarisAOttenhoffTHMHaksMC

The design of the screen is essential since your screen should be selective enough to eliminate non-useful variants, but not so stringent as to eliminate all variants

Such particles are formed in the body and can harm cells when their numbers soar too high

For example, bortezomib, a first-generation proteasome inhibitor that suppresses NF-B signalling and is approved for haematological malignancies, is associated with dose-limiting peripheral neuropathy, for which no approved prophylactic or therapeutic interventions currently exist [51, 52]

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