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Computational improvements reveal great bacterial diversity and high metal toxicity in soil

Proc Natl Acad Sci U S A (2012) 109(43):1753742

Oral semaglutide and cardiovascular outcomes in high-risk type 2 diabetes

Excess copper is reduced by FDX1 to generate Cu, which drives cell death via two primary mechanisms: (1) Cu-mediated aggregation of lipoylated TCA cycle proteins (e.g., DLAT) and loss of Fe-S clusters, and (2) Cu-induced disruption of the Npl4/p97 protein quality-control system

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