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Research indicates that GCG excess, rather than insulin deficiency, is crucial for diabetes pathogenesis

Wang Y, Leak RK, Cao G (2022) Microglia-mediated neuroinflammation and neuroplasticity after stroke

In addition, this period involves increased NADPH synthesis by redirecting glucose metabolism through the pentose phosphate pathway (PPP)

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One study suggested that hyperglycemia in patients with diabetes could affect thiamin re-uptake by decreasing the expression of thiamin transporters in the kidneys (42)