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Systemic Allergic Reactions (Anaphylaxis) Her are some warning signs requiring immediate emergency services: Generalized urticaria (hives) or widespread itching beyond injection site Swelling of lips, face, tongue, or throat Shortness of breath, wheeze, chest tightness, difficulty breathing Dizziness, lightheadedness, syncope Rapid heart rate with pallor, collapse, or hypotension Call 911 immediately, as anaphylaxis requires epinephrine and emergency care