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TGR5, expressed in brain and peripheral neurons, as well as glial and microglial cells, can be activated by several neurosteroids (305)

Sirtuins, particularly SIRT1, are involved in promoting mitochondrial biogenesis and enhancing cellular stress resistance, thereby supporting overall cellular health

However, the balance between Mn sufficiency and toxicity is narrow, and dysregulation contributes to a spectrum of pathologies ranging from neurodegeneration to metabolic and inflammatory diseases

ruminis also possess the fusion protein but GSH synthesis has not been established in these organisms

In addition, there are a number of van der Waals contacts between the two helices