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Accordingly, in vivo administration of NAC attenuates the acute colitis through increased mucosal GSH levels, suggesting that GSH precursors may be of relevance in the acute relapse of IBD

The eosinophilia was gradually replaced by neutrophilia in adult mice, while eotaxin-1 levels decreased and GRO- levels increased, examination of DCs activation revealed increased DCs activation in the lungs of SLC7A2-deficient mice (131)

Sapolsky RM, Romero LM, Munck AU

Concurrently, it activates mTOR to enhance glycolysis and IL-2 autocrine signaling, synergizing with butyrate for robust antigen-specific T cell expansion (108)

It is interesting to note that immune cells like microglia and macrophages shift from oxidative phosphorylation (typical of M2 type phenotype), which corresponds to an inactive state, to aerobic glycolysis (typical of M1 type phenotype), which corresponds to a proinflammatory state [41,42]