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Only stereoisomers with an R -configuration in position 2 ( RRR , RSR , RRS , RSS ) are considered biologically active and meet human vitamin E requirements

Arterioscler Thromb Vasc Biol 17(11):28432847 Mohammad G, Kowluru RA (2020) Homocysteine disrupts balance between MMP-9 and its tissue inhibitor in diabetic retinopathy: the role of DNA methylation