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Second, ERKO/Wnt-1 mice, which have no functional ER-, develop estrogen-induced mammary tumors23-25

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As the crucial upstream node of SLC7A11/GSH/GPX4 signaling pathway, the inhibition of SLC7A11 leads to impaired antioxidant capacity, depleted GSH, inactivated GPX4, increased lipid ROS, ultimately induces ferroptosis in cancer cells (Jiang et al, 2021)

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Review of N-acetylcysteine for the treatment of acetaminophen (paracetamol) toxicity in pediatrics