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The essential elements of Alzheimer's disease

A group of acidic residues coordinates two Mg 2+ to ATP and orienting the -phosphate group in the active site

Pharmaceutics, 17(3), 385

Abbreviations 3-MST: 3-Mercaptopyruvate sulfurtransferase ALF: Acute liver failure AOAA: Aminooxyacetic acid CARS: Cysteinyl-tRNA synthetase CAT: Cysteine aminotransferase CBS: Cystathionine -synthase CNS: Central nervous system CO: Carbon monoxide CoQ: Coenzyme Q CSE: Cystathionine -lyase ETC: Electron transport chain ETHE1: Ethylmalonic encephalopathy 1 GalN: d-Galactosamine GSH: Glutathione GSSH: Glutathione persulfide H 2 S: Hydrogen sulfide HC: Hydroxocobalamin I/R: Ischemia/reperfusion LPS: Lipopolysaccharide MetHb: Methemoglobin NO: Nitric oxide O 2 : Oxygen PAG: dl-Propargyl glycine PLP: Pyridoxal 5-phosphate SDO: Sulfide dioxygenase SO: Sulfite oxidase SOU: Sulfide oxidation unit SQR: Sulfide quinone oxidoreductase STS: Sodium thiosulfate TNF-: Tumor necrosis factor TST: Rhodanese or thiosulfate sulfurtransferase References Reiffenstein RJ, Hulbert WC, Roth SH (1992) Toxicology of hydrogen sulfide

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