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Psychopharmacology 237 , 27392752 (2020)

Unlike other bacteria, Mtb has only one fumarase (Rv1098c), making it a vulnerable and attractive therapeutic target for drug development against Mtb [8, 223, 286]

The exact mechanisms of PACS may be multiply overlapping, several hypotheses have been proposed, including persistent viral existence in tissues, dysfunction of vascular endothelium and nervous system, reactivation of latent pathogens and gut microbiota alteration, long-lasting inflammation, and immune dysregulation (Davis et al., 2023)

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