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Computational identification of natural senotherapeutic compounds that mimic dasatinib based on gene expression data

Blood samples All animals tested were randomly chosen from controlled farms of the Latium and Tuscany countrysides

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[5], [6], [7] Transcription factors of the FOXO family specifically FOXO1, FOXO3, FOXO4, and FOXO6 are key mediators of insulin and IGF signaling, participating in the regulation of a wide range of cellular processes, including metabolism, cell growth and differentiation, response to oxidative stress, autophagy, senescence, and aging-related processes

Experimental studies explore how the compound behaves in environments replicating gastric acidity, mucosal damage, and chemically induced erosion