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J Hepatol 2016;64:S173-4

1i), as well as to N238 and S237-N238 amide backbone (not shown)

To assess oxidative stress of TRPM7-Zn 2+ -induced pyroptosis, mitochondrial membrane potential (MMP) and ROS production were examined in N2a cells treated with PILO, PILO combined with TRPM7 siRNA transfection, or PILO combined with 1 M TPEN with the JC-1 and DCFH-DA dyes (fluorescent probe 2,7-Dichlorodi-hydrofluorescein diacetate (DCFH-DA))