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In the past decades, pre-clinical animal models for CIPN studies are successfully established to study the neurotoxicity of chemotherapeutic agents, including paclitaxel (Polomano et al., 2001

35 The negative effect of CRP on the vascular wall has been confirmed by studies of its interaction with angiotensin II and its effects on the integrity of the endothelial glycocalyx, 36,37 as well as on increased expression of the lectin-like oxidized low-density lipoprotein receptor-1 involved in the damaging effect of oxidized low-density lipoproteins (ox-LDL)

Most skin whitening pills are sold as dietary supplements and are never subjected to any health authority's rigid scientific testing and approval processes in many countries

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However, translating these promising findings into clinical success remains a formidable challenge