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Regulatory, Integrative and Comparative Physiology, vol

[64] did not improve outcomes over conservative care, suggesting that extremely high concentrations may not enhance efficacy

Various clinical studies are underway (Table 3)

At baseline serum GDNF concentrations were reduced in both medication-free manic and depressed bipolar patients, compared to the control group

Additionally, small-molecule chaperones, aldose reductase inhibitors, and protein aggregation inhibitors have also demonstrated potential in stabilizing or restoring lens protein structure and transparency