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Alzheimers disease is the most common age-associated neurodegenerative disease and requires an effective therapeutic strategy due to its increasing socioeconomic burden

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Results Rb promotes GBM cell damage and induces mitochondrial dysfunction and oxidative stress Rb increases LDH release in U87 and U251 cells To evaluate the cytotoxicity of Rb, U87 and U251 cells were treated with various concentrations of RbCl

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Trx system The Trx system consists of Trx-interacting protein (TXNIP), Trx, Trx reductase (TrxR) and NADPH, which serve an important role in growth promotion, apoptosis, inflammation regulation, antioxidant defense and maintenance of redox state homeostasis (15)