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Tumour acidosis: from the passenger to the driver's seat

For example, in models of prolonged MV, O exposure, or chronic smoking, hippocampal microglia can be activated by HMGB1 via the TLR4-NLRP3 axis, thereby interfering with TREM2 expression and subsequently severely compromising microglial ability to clear A plaques, exacerbating AD-related pathology [59, 187, 399]

Introduction You can think of the sequences of bases in the coding strand of DNA or in messenger RNA as coded instructions for building protein chains out of amino acids

DOI: 10.1073/pnas.2213041119 Wang, H.J., Evans, R.M

In addition, PRs are recognized as the most highly metabolically active cells in the retina, owing to the vigorous oxidative metabolism within the mitochondria exclusively localized in the inner segments of PR cells (105)