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5.3 Crizotinib Mutations in RAS isoforms are a common occurrence in human cancers ( SCH51344, though not used clinically, led to the identification of crizotinib, a widely used dual Met/ALK inhibitor, as a potent inhibitor of MTH1 activity

10.3389/fncel.2021.787258 162 SarletteA.KrampflK.GrotheC.NeuhoffN

Ngoi ra cn c cc phn ng d ng nh kh th, tc ngc, kh nut hoc ni chuyn, st, pht ban, ni m ay, nga, Khi gp cc phn ng trn, bn cn n gp bc s c iu tr cc triu chng trn

Use according to claim 2, for in vitro and/or in vivo modulation of the cold and menthol receptor TRPM8, preferably as TRPM8 receptor agonist

Notably, GPX4 or FSP1 cannot substitute for the protective role of DHODH, highlighting the uniqueness of the mitochondrial localized defense system