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The muscle-sparing effects become most apparent during this phase as fat loss continues without corresponding muscle loss

Purified recombinant protein (3 g) was resolved using 18% w/v SDS-PAGE in reduced (+-mercaptothanol, R) and non-reduced (NR) conditions and stained with Coomassie Brilliant Blue R250

Epub 2009 Mar 16

Studies of global IGF-I KO mice (50,51), which survive to adulthood, show decreased bone formation rates, but higher trabecular bone mass (BV/TV), indicating reduction in both osteogenic and osteoclastogenic activities in the bones