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Tobacco dependence is also recognized as a disease in the World Health Organization's International Classification of Diseases (ICD-10) and the American Psychiatric Association's Diagnostic and Statistical Manual (DSM-IV) [2, 3]

Though he notes that this should not be reason in and of itself not to curb sales at brick-and-mortar vaping stores, he says that a federal ban on flavored e-cigarettes would likely be far more effective (indeed, the FDA has proposed a ban on flavored e-cigarettes, though former Commissioner Scott Gottlieb resigned before such policies could be implemented)

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Chronic excess (typically 25-50mg daily over extended periods) can impair immune function, reduce HDL cholesterol, and cause copper deficiency leading to anaemia and neurological problems