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On one side, peroxynitrite formation can be a mechanism to consume superoxide thereby protecting biomolecules from oxidation and preventing further ROS production (Kanner et al., 1991

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showed that glycyrrhizin can prevent ferroptosis in cells and in an animal model of acute liver failure by regulating iron levels, the GSH/GPX4 pathway, and the NRF2/HO-1/HMGB1 pathway

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doi: 10.1016/j.freeradbiomed.2011.06.011 136

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