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Initial clinical failures, like that seen with VNP20009, have enlightened: a bacterial therapy for maximal efficacy should not be based on the removal of overall virulence, but on fine-tuned spatiotemporal control, provided by tools such as synthetic gene circuits (e.g., SLC and Cello)

PEDF is only highly expressed in undifferentiated human retinal cells, like Y79 retinoblastoma cells, but is either absent or down-regulated in their differentiated counterparts

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Importantly, it is the only reversible lipid post-translational modification (PTM) identified to date 13 and thus can dynamically regulate the function of proteins

(PUT/JKT) Referensi: Medical News Today