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High-Fat, High-Sucrose Diet (HFHS) feeding markedly elevates hepatic triglyceride and cholesterol in male LDLR/ mice on C57BL/6J background, while S17834 activates AMPK, inhibits sterol regulatory element-binding protein (SREBP), and reduces these lipid parameters by 40%50%, validating the AMPK-SREBP axis as a key regulator of hepatic lipid accumulation

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9 , e1003530 (2013)