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Current research has not yet fully elucidated why TINs exhibit both susceptibility and resistance to ferroptosis across different tumor types or even within the same tumor model

At the methodological level, isotope tracing technologies can directly resolve actual metabolic flux changes, single-cell and spatial multi-omics can help identify cell-cell interactions and substrate competition in the tissue microenvironment, and genome-scale metabolic modeling can be used for priority ranking and assessment of targetability

In addition to mitochondrial dysfunction, lipid dysregulation is another hallmark of ALS pathology (Abdel-Khalik et al., 2017)

Ectopic expression of MT1 and MT2 (from Brassica campestris ) in A

( 2 O 2 and induced by Zn stress (Tsuji et al., 2002), indicating that exogenous GSH-induced PCs may be directly involved in the removal of ROS in Cd-exposed plants