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(2021) 11:e372

Observations on the etiologic relationship of achylia gastrica to pernicious anaemia

According to the current paradigm, glutamate-driven excitotoxicity, activation of calcium-dependent proteases, over activation of calcium-regulated kinases and phosphatases, and mitochondrial calcium overload resulting in mPTP opening (53, 54) are some of the mechanisms by which generalized calcium overload in neurons causes neuronal death (54, 55)