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JAMA Psychiatry 78:481

10.3389/fcimb.2022.924119 Front

By Feb 2023, 20 patients had developed HCC and they were all early stage disease

Third, not all POIs are equally amenable to CRBN- or VHL-based degraders, possibly due to incompatibilities in surface topologies and hence an inability to form a productive ternary complex 21,22,23