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Both compounds target the pituitary gland to stimulate growth hormone release through receptor-level mechanisms, yet they differ in pathway, half-life, and selectivity, producing distinct research profiles relevant to body composition, fat loss, and lean muscle outcomes

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We acknowledge Melanie Lingaya, Ryan Criswell, Deborah Hart, James Stejskal, Richard Giovanelli, Kelly Fader, and Heather Llewellyn for their assistance with sample processing

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Methods GHSR expression and purification All primers used in this study are listed in Supplementary Table 2