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4 Discussion 4.1 Main findings To our knowledge, this is the first comprehensive characterization of intestinal mucosal alterations in the CPZ model, a widely accepted preclinical model of reversible CNS demyelination

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The dimer interface is formed by the interaction between loop 2 of one monomer and loop 1 of the other, stabilized by hydrogen bonds and salt bridges, resulting in a more open and flexible active site pocket compared to other GCTs

Similarly, ADH-D has been identified as a predictor of sex-independent weight gain, being correlated with BMI and waist circumference in surgically treated patients with CP [75]