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Paeoniflorin attenuates hepatic ischemia/reperfusion injury via anti-oxidative, anti-inflammatory and anti-apoptotic pathways

Senescent macrophages release inflammatory cytokines and RNA-loaded extracellular vesicles to circumvent fibroblast senescence

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In contrast, it significantly improves anti-PD-1 responses in PD-1 refractory microsatellite stable CRC

Specifically, dysregulated neuronal energy metabolism can trigger apoptotic cascades via mitochondrial membrane potential collapse or abnormal pyruvate dehydrogenase complex phosphorylation, while targeting monocarboxylate transporter MCT2-mediated lactate shuttling or mitochondrial calcium uniporter (MCU) activity has emerged as a promising therapeutic strategy for neurodegenerative disorders