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Treatment of sphingosine-1-phosphate (S1P) or S1P receptor agonists increases DUSP6 protein levels and reduces monocyte adhesion in the murine primary aortic endothelial cells

This makes it a poor medication as you would have to take it every 20 minutes to maintain its levels in the blood

The alanine substitution at position 15 provides resistance to endopeptidase cleavage, and the leucine substitution at position 27 improves overall peptide stability, creating a molecule with dramatically extended biological activity compared to natural GHRH

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