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Almost 90% of cellular GSH are in the cytosol, 10% is in the mitochondria and a small percentage is in the endoplasmic reticulum (Meredith and Reed 1982)

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Associated with HU, HDAC gene inhibition produced a more pronounced increase of -globin and HbF ( DNA Methyltransferase 1 is involved in the shutting down of -globin gene after birth and its subsequent production

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