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We summarize mechanistic insights across cellular and molecular domains, critically appraise preclinical and clinical findings, and discuss translational challenges that include bioavailability and brain penetration, study heterogeneity, biomarker guided stratification, and pediatric safety

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At the protein level, we noticed that the expression of GLS and glutamine transporters responsible for shuttling glutamine into the cytosol (SLC1A5, SLC38A1) were significantly elevated in tumors compared to livers of the tumor-bearing mice (Supplementary Fig