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The reciprocal production of keratin sulfate and chondroitin sulfate as the IVD ages is thought to be secondary to the lack of oxygen supply to the centrally growing disc as a result of both growth and decline in vascularity

This regulatory effect helps preserve collagen integrity, maintain epithelial barriers, and reduce inflammation-driven degradation associated with aging and chronic stress

Statistical inference in two-sample summary-data Mendelian randomization using robust adjusted profile score

Nicholas John Stacey, junior, Deans List, College of Business, marketing

At present, we cannot explain this phenomenon