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Binding of BRD4 ET to ASXLs is conserved ASXL1 and homologous ASXL2 and ASXL3 were identified as mutually exclusive components of the PR-DUB complex 1,29 , and all contain similar but not identical ET-binding sequences (IRIQL in ASXL1, LKIPV in ASXL2 and LKIQL in ASXL3) (Supplementary Fig

The principal mode of action for albendazole is by its inhibitory effect on tubulin polymerization which results in the loss of cytoplasmic microtubules