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First, the Mayo Clinic trials abruptly stopped the ascorbate administration, switching to traditional chemotherapy, when the patient developed signs of tumor progression

Nevertheless, advances in neuroimaging, biomarker analysis, and longitudinal cohort studies have enabled researchers to corroborate key mechanistic pathways in humans, particularly those involving neurotrophic deficits, hippocampal atrophy, and neurotransmitter dysregulation

The metabolic state created by significant caloric restriction activates pathways that break down muscle tissue to provide amino acids for gluconeogenesis and other essential processes

24 These mutations serve as key molecular discriminators between glioma subtypes and are highly prevalent in lower-grade diffuse gliomas (WHO grades IIIII) and secondary GBMs 25 but are largely absent in primary GBMs, which are predominantly IDH wild-type

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