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In glaucomatous lamina cribrosa cells, increased levels of unmethylated DNA in the TGF1 promoter were observed, along with increased expression of TGF 1, TGF2 , COL1A1 , and -SMA (McDonnell et al., 2016), ultimately promoting fibrosis (Figure 5E)

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First, the bioavailability and hepatic delivery of many dietary antioxidants (e.g., polyphenols, vitamins C and E) are often low and highly variable between individuals