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For example, L-ascorbic acid, a form of vitamin C found in many skin care products, degrades when it is exposed to heat, a high pH or sunlight, she said which can happen during transit and storage. And then theres the question of sufficient penetration into the skin barrier to allow Vitamin C to do what it needs to do to truly promote your skin health

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PLoS Med 2005

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DNA methylation patterns can be disturbed because of the depletion of GSH when it is chronically consumed for conjugation of chemicals and their metabolites