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Atkuri et al

Parsad D, Pandhi R, Juneja A

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Studies of enzyme kinetics revealed that the Michaelis constant (Km) values of PHDs for O 2 are higher than those of CPHs, which results in the capacity of PHDs to sense changes in cellular oxygen levels [38]

However, AARS is an exception, which relies on lactate-AMP as an intermediate to directly transfer lactyl group to the lysine residues of target proteins with the assistance of ATP [25, 26] As the most well-studied writer, p300-catalyzed lactylation mainly promotes gene transcription [28,29,30,31,32,33,34,35,36,37,38,39] and maintains normal protein structure and functions [40,41,42,43,44,45]