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Using this approach, we discovered a novel role for the melanogenesis-associated transcription factor, or MITF, in repressing the expression of innate immune genes within cells of the melanocyte lineage in mice. The importance of this repression is revealed in animals that have a predisposition for hair-graying

Transition metal iron and copper catalyze the formation of oxygen free radicals after myocardial IR (Spencer et al., 1998)

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This encompasses factors include internalization, recycling, turnover rates, lysosomal degradation, and obligate mechanisms [26]