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2021;13(15):19186-19206 Calderon-Larranaga A

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METAOD002: A Phase IIa (double-blind, placebo-controlled 4 4 Latin Square design) safety study with single doses (25, 50 and 100 g/kg AOD9604) administered intravenously to 23 healthy clinically obese males presenting with a BMI 35 kg/m 2

Notably, HIF-1 mediates adaptive metabolic responses to hypoxia by enhancing glycolytic pathway, serine synthesis and one-carbon metabolism to promote mitochondrial antioxidant production (NADPH and GSH), and inhibiting the TCA cycle so as to diminish mitochondrial ROS production (247)