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Suprewicz et al., 2023)

A large-scale prospective study is needed to understand the underlying mechanisms of lipid-induced hepatic dysfunction in the Bangladeshi population

The increased production of reactive oxygen species (ROS) from inflammatory cells and exposure to oxidants from inhaled sources contribute to the elevated oxidative stress observed in COPD, potentially leading to an exacerbated inflammatory response and the generation of lipid peroxidation products [115]

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IL-6 acting via JAK/STAT3 signaling stimulates hepatic glucose production and enhances fatty-acid oxidation by increasing PPAR expression