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This metabolic alteration results in enhanced activation and differentiation of T-cells, culminating in the excessive production of pro-inflammatory cytokines, such as IFN- and TNF-

While IL-17 alone does not inhibit pigmentation, it significantly amplifies the inhibitory effect of TNF on melanin synthesis through a synergistic interaction (Wang et al., 2013)

PLoS One 10 (6), e0130546