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Indeed, SLC1A5 is highly expressed in various solid cancers 73,76,77 , such as squamous lung cancer, in which it is responsible for approximately 50% of glutamine uptake 73

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Nature 592 , 524533 (2021)

From the previous section, it follows that inherited disorders leading to dramatic elevations of homocysteine in the blood and urine derive from genetic defects in homocysteine transsulfuration or re-methylation, or in the transporters and enzymes involved in the delivery and metabolism of the key cofactors required for these metabolic pathways (specifically folate and vitamin B12)