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Notably, even though acetylation modification exists on GCLC, its level is not affected by manipulating SIRT2 expression

Herein, the optimization pathways of existing therapeutics and emerging therapeutic directions are systematically reviewed, with particular emphasis on their mechanisms of action, current clinical application status, and future potential, with the aim of providing guidance for personalized IBD management

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For experiments, a working concentration of 4 M was freshly prepared by diluting the stock solution in complete culture medium, yielding a final DMSO concentration of 0.1%

Sig Transduct Target Ther 11 , 224 (2026)