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Mood : anxiety, depression sometimes to the point of suicidality

doi: 10.1016/j.freeradbiomed.2011.07.014 284 WangKPengBXiaoJWeinrebOYoudimMBHLinB

The findings call for rejecting our study hypothesis, which was based on suggestions that the physiological effects and emotional burdens of daily bedtime injections, including injection-related fear, anxiety, and stigma (5), could affect sleep-wake pattern, total sleep time, sleep efficiency, number of arousals, and daytime activity

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Another is the development of more efficient delivery systems, particularly for systemic therapies, to ensure adequate bioavailability